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By Laura Dolson

Protein: How Much Do You Need?

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By Dan Wetzel

Lesnar’s rocky road takes another turn

Last month Brock Lesnar sat in a small-town, fast food restaurant, surrounded by blue-collar townies, munching on a five-dollar foot long. He was the reigning Ultimate Fighting Championship heavyweight title holder, yet unlike his old days as a profession
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By Bryan Smith

Exotic juice health claims are pure pulp fiction

They arrive early and join a line that stretches out like a Sunday morning communion queue: flip-flopped tourists in madras-print vestments, joggers ashine from their early-morning canters, locals burning off the fog of a few too many.
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Lasix

Description:  Lasix is a brand name for the drug furosemide, a very potent diuretic. Technically it belongs to a class of drugs known as loop diuretics, which will cause the body to excrete water as well as potassium, sodium and chloride. Loop diuretics are among the strongest such drugs available, having an extremely dramatic effect on fluid levels in the body. Potassium levels need to be particularly watched, Lasix greatly increasing the amount excreted. The use of a prescription potassium supplement therefore is often required to keep levels in balance, otherwise a serious heart complications might develop. Mistakes in potassium dosage have equally serious consequences, so Lasix is clearly a risky item to use. But when an athlete needs to shed water, it is very difficult to find something that works better.

Athletes use diuretics for a couple of specific purposes. Competitive athletes use these drugs to drop water weight, in an effort to make adjustments in their weight class standings. Since the weigh-in is most often a day or days before a competition/match, one can drop their bodyweight considerably and be back to normal within hours after rehydration. This logically seems to provide an unfair advantage, the athlete competing at a much heavier weight than believed. This advantage is only offset by the now near universal nature of this practice. Bodybuilders also rely heavily on diuretics when preparing for a contest. It can efficiently lower subcutaneous water concentrations, helping to produce that super-ripped look so common on stage today. Make no mistake; a winning look is extremely difficult to obtain without some form of diuretic.

This drug is prepared as both an oral tablet (usually 20-40mg per tablet) or IM/IV injection solution, the injection being much more rapid in effect. The dosage and method of administration is tailored to the individual, dependent on the desired goals and condition of the athlete. Tablets are the most common form of administration. Each oral Lasix tablet becomes effective about 1 hour after ingesting and will remain active for an additional 3 or 4 hours. The athlete will usually start with a mild dose, and add to this amount accordingly later in the day. The initial dosage is usually 20 to 40mg, with the maximum amount usually not to exceed 80mg. The user will attempt to calculate the optimal dosage, and determine the best intake schedule in relation to the show or competition. In order to minimize the side effects associated with this drug, it is generally used for no longer than a few days.

Since Lasix has such a strong effect on electrolyte and potassium levels, it is much safer to addition a potassium sparing agent like Aldactone® (spironolactone) than it is to keep increasing the amount of Lasix used. A combination of 50mg Aldactone® and 20mg Lasix would be a good starting point, having roughly the effect of a 40mg Lasix tablet without the notable potassium loss. This dosage is repeated 2-3 times during the day and the effect judged to determine the optimal dosage. It is important to remember that these drugs can be active for many hours. It can become difficult to control the dehydrating effect with an overlapping schedule, so one should be careful not to administer such diuretics too frequently.

Lasix is no doubt one of the most dangerous drugs a competitor will use. This can be seen on occasion when severe dehydration and electrolyte imbalance takes the life of an ambitious athlete. Warning signs that Lasix may be causing severe dehydration include (not limited to) dizziness, cramping, vomiting, diarrhea, fainting and circulatory disturbances. Potassium depletion can be marked as well, so as discussed users often opt to take a prescription potassium supplement, also with its own set of dangers. One should use extreme caution when considering using Lasix or other diuretics; they are certainly not needed for recreational users.

This product is widely available. It is manufactured and sold under many different brand names, in many countries. No version of Lasix (or any other diuretic) is currently being counterfeited. When found on the black market it can therefore be trusted. Although it is doubtful these will circulate, make sure never to purchase the 500mg tablets. These are used only in severe medical conditions, and contain a dosage that could prove fatal to a healthy person.
 
Chemical name:  Furosemide
 
Chem. Abstr. Name:  5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoic acid
 
Molecular Weight:  330.745g/mol
 
Molecular Structure: C12H11CIN2O5S
 
CAS Number:  54-31-9
 
Merck Index Number: n/a
 
Metabolism:  Hepatic and Renal
 
Excretion:  Renal 66%, Biliary 33%
 
Elimination Half Life: 2 hours

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