Lamisil
Description: Terbinafine hydrochloride (Lamisil® in UK & US) is a synthetic allylamine antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Terbinafine hydrochloride is a white fine crystalline powder that is freely soluble in methanol and methylene chloride, soluble in ethanol, and slightly soluble in water.
Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the fungal cell wall synthesis pathway (NB: the fungal cell wall, not the cell membrane). In layman's terms, it inhibits fungal and bacterial cell wall growth, causing the contents of the cell to be unprotected and eventually die.
Chemical name: Terinafine
Chem. Abstr. Name: N,6,6-trimethyl-N-(naphthalen-1-ylmethyl) hept-2-en-4-yn-1-amine
Molecular Weight: 291.43g/mol
Molecular Structure: C21H25N
CAS Number: 91161-71-6
Merck Index Number: n/a
Metabolism: Hepatic
Excretion: n/a
Elimination Half Life: 36 hours
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